Gene MMAR_0717 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethiE
Gene length663 bp
IdentifierMMAR_0717
Location 863746 bp
Protein summary information
Molecular mass23065.3 Da
Isoelectric point6.09
Protein length221 amino acids
Structural information
PFAMB2HPZ9
Orthologues
M. tuberculosisRv0414c
Cross-references
UniProtB2HPZ9
Gene OntologyMagnesium ion binding, Thiamine biosynthetic process, Thiamine-phosphate diphosphorylase activity
Enzyme Classification2.5.1.3
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in thiamine biosynthesis. condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate (thz-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [catalytic activity: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamine monophosphate].
Productthiamine-phosphate pyrophosphorylase ThiE
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS863746864408-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_0717|thiE
VHSRLATARLYLCTDARRERGDLADFADAALAGGVDIIQLRDKGSAGEQRFGPLEARDELAACEILADAAARHAAMFAVNDRADIARAARADVLHLGQRDLPVDVARAITGPATLIGQSTHDRDQVSAAAIGAVDYFCVGPCWPTPTKPGRTAPGLDLVRFAADVAGAKPWFAIGGIDGVRLPEVLAAGARRIVVVRAITAADDPREAAAKLKSELLAAI
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