Gene MMAR_0843 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemC
Gene length945 bp
IdentifierMMAR_0843
Location 1007599 bp
Protein summary information
Molecular mass32562.9 Da
Isoelectric point4.77
Protein length315 amino acids
Structural information
PFAMB2HRJ2
Orthologues
M. tuberculosisRv0510
Cross-references
UniProtB2HRJ2
Gene OntologyHydroxymethylbilane synthase activity, Porphyrin-containing compound biosynthetic process
Enzyme Classification2.5.1.61
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in porphyrin biosynthesis by the C5 pathway (at the fourth step). tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane preuroporphyrinogen in several discrete steps [catalytic activity: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3].
Productporphobilinogen deaminase HemC
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS10075991008543+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_0843|hemC
VIRIGTRGSLLATTQAATVRDALIANGHAAELVTISTLGDRSSAPIETLGVGVFTTALREAIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPPRQDPRDAVVARDGLVLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGAIAEVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVAAELFELGARELMWGEGNSPQGS
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