Gene MMAR_0901 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemenD
Gene length1647 bp
IdentifierMMAR_0901
Location 1092483 bp
Protein summary information
Molecular mass57351.2 Da
Isoelectric point6.19
Protein length549 amino acids
Structural information
PFAMB2HRP6
Orthologs
M. tuberculosis H37RvRv0555
Cross-references
UniProtB2HRP6
Gene Ontology2-oxoglutarate decarboxylase activity, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity, Magnesium ion binding, Manganese ion binding, Menaquinone biosynthetic process, Thiamine pyrophosphate binding
Enzyme Classification2.2.1.9
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in menaquinone biosynthesis (at the first step) [catalytic activity 1: isochorismate + 2-ketoglutarate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO(2)] [catalytic activity 2: 2-oxoglutarate = succinate semialdehyde + CO(2)].
Productbifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, MenD
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS10924831094129+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_0901|menD
VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGFLAIGLAVGAGAPACVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRATISLGLAEDAHERLDSLNASWRSATCRVLAAAMGSRTANAGPVHFDIPLREPLVPDPEPHGAVTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNLVQLPTIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPEVPVFALTTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAAVREQLAAHPLTTGLHVAAAVAGALRPGDQLVLGASNPVRDAALVGLDTAGLRVRSNRGVAGIDGTVSTAIGAALGYERDHHGRTVALIGDLTFVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKADRSSLRQLHAAIKAAL
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