Gene MMAR_1257 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namebirA
Gene length831 bp
IdentifierMMAR_1257
Location 1537278 bp
Protein summary information
Molecular mass28874.8 Da
Isoelectric point5.5
Protein length277 amino acids
Structural information
PFAMB2HEK8
Orthologs
M. tuberculosis H37RvRv3279c
Cross-references
UniProtB2HEK8
Gene OntologyBiotin-[acetyl-coa-carboxylase] ligase activity, Cellular protein modification process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionBirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [catalytic activity: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP forming)] = AMP + pyrophosphate + [acetyl-CoA:carbon-dioxide ligase (ADP forming)]].
Productbifunctional protein BirA
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS15372781538108+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_1257|birA
VTDRDQLRLPLDASKLRSEAIDSGWRQLDVVDETGSTNADLLARAAAGADIEGAVLIAEHQTAGRGRLGRGWSATARAQITMSVGVRVDGVPTATWGWLSLATGLAVVDTVTPLLDGTAAQAGLKWPNDVLAGPPGSLGKLAGILAEVAMPYAVIGIGLNVTQAPDEIAGPAATSLLDLGVPAPDRNELAARLLRELAARIDEFRRAHARLSADYRARSLTIGSRVRAQLPGGREIVGIARDIDEQGRLRLQTTPDEAGKSGETVVVAAGDVVHLR
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