Gene MMAR_1260 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepurK
Gene length1215 bp
IdentifierMMAR_1260
Location 1539427 bp
Protein summary information
Molecular mass43214.3 Da
Isoelectric point5.47
Protein length405 amino acids
Structural information
PFAMB2HEL1
Orthologs
M. tuberculosis H37RvRv3276c
Cross-references
UniProtB2HEL1
Gene Ontology'de novo' imp biosynthetic process, Atp binding, Phosphoribosylaminoimidazole carboxylase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in purine biosynthesis (sixth step). possesses an ATPase activity that is dependent on the presence of air (aminoimidazole ribonucleotide). the association of PurK and PurE produces an enzyme complex capable of converting air to cair efficiently under physiological condition [catalytic activity: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate = 1-(5-phosphoribosyl)-5-aminoimidazole + CO(2)].
Productphosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AirC)
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS15394271540641+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_1260|purK
MMAVPSSRTPQVAMVGGGQLARMTHQAAIALGQNLRVLVNSADDPAAQVTPNVVIGSHTDLDDLRRIAAGADVVTFDHEHVPAELLDKLVAEGVVLAPPPQALVHAQDKLVMRRRLQALDVPVPRYLGIHQLEELGELDAFARELDAPLVVKAVRGGYDGRGVQMARDLADARDIASGYLAGGVPVLVEERVQLRRELSALVARSPFGQGAAWPVVETVQQDGICVAVIAPAPALSAQAGADAQQLALRLAAELGVVGVLAVELFETTDGALVVNELAMRPHNSGHWTMDGSRTSQFEQHLRAVLDYPLGDTEAIAPVTVMTNVLGAAAQPAMSLDERLHHLFARMPDARVHLYGKDERPGRKVGHINFLGFDPAAVAGLRERAELAAHWLSHGQWTDGWDPHG
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