Gene MMAR_1778
in Mycobacterium marinum M
General annotation
| Type | CDS |
| Function | Involved in phthiocerol dimycocerosate (PDIM) and phenolic glycolipid (PGL) biosynthesis. In M. tuberculosis H37Rv TesA interacts with the PpsE protein. PpsE is part of the phenolphthiocerol synthase PKS cluster. |
| Product | thioesterase TesA |
| Comments | - |
| Functional category | Lipid metabolism |
| Mutant | M. marinum tesA|MMAR_1778 transposon mutant lacks PDIM A, PDIM B, and PGLs, defect corrected by complemetation; mutant is more susceptible to some antibiotics (partially complemented by tesA expression) but not isoniazid (See Alibaud et al., 2011). M. marinum tesA|MMAR_1778 deletion mutant produces only trace amounts of PDIMs and PGLs, defect corrected by complementation with tesA but not tesA-S92A; mutant is more susceptible to several antibiotics (complemented by tesA expression) but not streptomycin (See Chavadi et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2172321 | 2173070 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium marinum M|MMAR_1778|tesA
VNGRSSNSKSDEKLTAPTLYIFPHAGGTAKDYVPFAKEFSGEVKRVAVQYPGQQDGYGLPPLESIPGLAEEIFAIMKPAARIDTPVALFGHSMGGMLAFEVALRFEAAGYRVLALFLSACSAPGHIKYKQLKGYSDNEMLDLVARATGTDPEFFNDEEFRVGVLPTLRAVRAIAGYSCPPENKLSCPIYTFIGSKDWIATREDMEPWRERTTGDFSLREFPGDHFYLNKNLPELVSDIEIGTLQQFDQI
Bibliography
- [2011]. A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos. Function Mutant
- [2011]. Inactivation of tesA reduces cell wall lipid production and increases drug susceptibility in mycobacteria. Function Mutant
