Gene MMAR_1838 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameispG
Gene length1164 bp
IdentifierMMAR_1838
Location 2237857 bp
Protein summary information
Molecular mass40628.4 Da
Isoelectric point5.14
Protein length388 amino acids
Structural information
PFAMB2HJQ1
Orthologs
M. tuberculosis H37RvRv2868c
Cross-references
UniProtB2HJQ1
Gene Ontology4 iron, 4 sulfur cluster binding, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity, Iron ion binding, Oxidation-reduction process, Terpenoid biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
Functionconverts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (by similarity).[catalytic activity] (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol.[cofactor] binds 1 4Fe-4S cluster (by similarity).
Product4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, IspG
Comments-
Functional categoryLipid metabolism
Coordinates
TypeStartEndOrientation
CDS22378572239020+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_1838|ispG
VTTGLGIPQPPAPTLSPRRTTRQLMVRDVGVGSDYPVSVQSMCTTKTHDVNATLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVIADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMQKYGKATPEALVESALWEASLFEEHGFGNIKISVKHNDPVIMVAAYEQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQILESLNLRPRSLEIVSCPSCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPEAQIVETLIEEAMRIAAEMGTEDPGTTSSGTPIVTVS
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