Gene MMAR_2395 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehisD
Gene length1344 bp
IdentifierMMAR_2395
Location 2891066 bp
Protein summary information
Molecular mass46285.5 Da
Isoelectric point5.28
Protein length448 amino acids
Structural information
PFAMB2HQA2
Orthologues
M. tuberculosisRv1599
Cross-references
UniProtB2HQA2
Gene OntologyNad binding, Histidine biosynthetic process, Histidinol dehydrogenase activity, Oxidation-reduction process, Zinc ion binding
Enzyme Classification1.1.1.23
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in histidine biosynthesis pathway (tenth step). this protein is considered as a bifunctional enzyme, possessing two active sites, one an alcohol dehydrogenase and the other an aldehyde dehydrogenase [catalytic activity : l-histidinol + 2 NAD(+) + H(2)O = L-histidine + 2 NADH].
Producthistidinol dehydrogenase HisD
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS28910662892409+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_2395|hisD
MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVAAVAERGAQAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVMIERTRAVHADQRRTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQASHGGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDVDGHELAPVDMITGPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLISQAEHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSAIILVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPVSLGDYCAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVLTLAKAEDLPAHGEAVRRRFER
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