Gene MMAR_3656 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameplcB_5
Gene length1551 bp
IdentifierMMAR_3656
Location 4502018 bp
Protein summary information
Molecular mass55967.2 Da
Isoelectric point6.0
Protein length517 amino acids
Structural information
PFAMB2HL96
Orthologs
M. tuberculosis H37RvRv2349c
Cross-references
UniProtB2HL96
Gene OntologyHydrolase activity, acting on ester bonds
Precomputed results
BLASTReport
General annotation
TypeCDS
Functionhydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate].
Productmembrane-associated phospholipase C 2 PlcB_5
Comments-
Functional categoryLipid metabolism
Coordinates
TypeStartEndOrientation
CDS45020184503568-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_3656|plcB_5
VSRDAFAGMSRREFMAKATGVGAGGFLTDWAAPVIEKAYAAGPCSGHLTDIEHIVLCLQENRSFDHYFGSLSSVDGFDTPTSLFQQKGWDPRTQSVDPAGTTVPYRIDTTRGPNGVGECVNDPDHQWIAAHLSWNGGGNDGWLAAQARTRSQANTPVVMGYYARPDIPIHYLLADTFTICDQYHSSLLGGTMPNRLYWISGTVNPDGDKGGPQIVEPTIQPKLTFSWRLMPENLSDAGVSWKVYNSKLLGGLNDTSLSRNGYVGSFKQAGDPRSDLARYGIAPRYPADFVLDIMNNRLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRALLRNPAVWEKTALIIAYDEHGGFFDHVTPPTPPEGTPGEWIPPTVDINTVDGSGGIRGPIGLGYRVPCFVISPYSRGGLLAHERFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAVPPNPSPPNLDHPAKQLPKLINCVPNAVLGFLNEGLPYRVPYPQTTPTQESGPVRGVPSGIC
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