Gene MMAR_3753 in Mycobacterium marinum M
Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproA
Gene length1272 bp
IdentifierMMAR_3753
Location 4618975 bp
Protein summary information
Molecular mass44565.5 Da
Isoelectric point5.48
Protein length424 amino acids
Structural information
PFAMB2HME9
Orthologues
M. tuberculosisRv2427c
Cross-references
UniProtB2HME9
Gene OntologyNadp binding, Cytoplasm, Glutamate-5-semialdehyde dehydrogenase activity, Oxidation-reduction process, Proline biosynthetic process
Enzyme Classification1.2.1.41
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in proline biosynthesis pathway (at the second step). catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. the product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. [catalytic activity: L-glutamate 5-semialdehyde + phosphate + NADP(+) = l-gamma-glutamyl 5-phosphate + NADPH].
Productgamma-glutamyl phosphate reductase protein ProA
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS46189754620246-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_3753|proA
MTLQAAPRSAAAQQREPDLRQEVHDAARRARVAARLLAVVPTGVKDRALHAAADAILAHVDRILSANAEDLDAARAADTPAAMLDRLALNPQRVDGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSSAARSNEALVNVLRSALDSEQLPADAVQLLSSADRSTVTHLIQARGLVDVAIPRGGAGLIDAVVRDAQVPTIETGVGNCHVYVHEAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAEHAMPRLIGALQDAGVTVHLDADEQDLRREYLAMEIAVAVVDGVDGAIAHINEYGTGHTEAIVTTNLAAAQRFTERIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIVWGEGHTRPA
Bibliography
No article yet recorded