Gene MMAR_4081
in Mycobacterium marinum M
General annotation
| Type | CDS |
| Function | involved in damage reversal and in base excision repair. the methylated Ada protein acts as a positive regulator of its own synthesis, as well as that of other proteins. the transcription-activating function of the Ada protein resides in its N-terminus. repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated. can also repair O-4-methylthymine [catalytic activity: DNA (containing 6-O-methylguanine) + [protein]-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine] |
| Product | Ada regulatory protein AlkA |
| Comments | - |
| Functional category | Information pathways |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 5028263 | 5029780 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium marinum M|MMAR_4081|alkA
MTLRRCNPLRVHEDFERCYRAVQSKDARFDGWFVTAVLTTRIYCRPSCPVRPPFARNVRFLPTAAAAQREGFRACKRCRPDASPGSPEWNVRGDIVARAMRLVADGTVDREGVTGLAARLGYTTRQLERLLQAEVGAGPLALARAQRMQTARVLIETTDLPFGDVAFAAGFSSIRQFNDTIRLVCDSTPTALRRHAAARFGAPATSPGTVSLRLPVRTPFAYQGVFGHLAAGAVPGCEEVRDGAYRRTLRLSSGNGIVTLTPAPDHVRCLLVLDDFRDLAAATARCRRLLDLDADPEAVVEALRGDPALGPVVATAPGQRIPRTVDEAELAVRAVLAQQVSTKAARTHAARLVTAYGRPIHDQGGTLTHTFPSVQDLAEIDPIHLAVPKTRQRTLSMMVDAIADRRVNLDAGCDWTRTREQLLDIPGVGPWTAEVIAMRGLGDPDAFPVADLGVRLAAKQLGLPQRQPGLLERSARWRPWRSYATQHLWTTLEHSVNDWPPREVA
Bibliography
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