Gene MMAR_4103 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethrA
Gene length1326 bp
IdentifierMMAR_4103
Location 5055077 bp
Protein summary information
Molecular mass45741.0 Da
Isoelectric point4.75
Protein length442 amino acids
Structural information
PFAMB2HQL8
Orthologs
M. tuberculosis H37RvRv1294
Cross-references
UniProtB2HQL8
Gene OntologyNadp binding, Amino acid binding, Homoserine dehydrogenase activity, Isoleucine biosynthetic process, Methionine biosynthetic process, Oxidation-reduction process, Threonine biosynthetic process
Enzyme Classification1.1.1.3
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in the conversion of l-aspartate to homoserine (third step). homoserine participates in the biosynthesis of threonine and then isoleucine and in the biosynthesis of methionine [catalytic activity : L-homoserine + NAD(P)(+) = l-aspartate 4-semialdehyde + NAD(P)H.]
Producthomoserine dehydrogenase ThrA
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS50550775056402-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_4103|thrA
VSGDVKPVGVAVLGLGNVGSEVVRIIEESADDLAARVGAPLVLRGVGVRRVADDRGVPIDLLTDDIEKLVSREDVDIVVEVMGPVEPSRKAILTALEHGKSVVTANKALLSTSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSEMDSTGADYAKALADAGALGYAEADPTADVEGFDAAAKAAILASIAFHTRVTADDVYREGITKITPADFASARALGCTIKLLSICERLTTDEGQQRVSARVYPALVPLSHPLATVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFISTRYYVSMNVADKAGVLSAVAAEFAKRDVSIAEVRQEGVVDQDGQRIGARIVVVTHLATDAALSETVEALADLDVVENVASVLRLEGNDL
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