Gene MMAR_5225 in Mycobacterium marinum M
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameleuA
Gene length1821 bp
IdentifierMMAR_5225
Location 6315323 bp
Protein summary information
Molecular mass66074.3 Da
Isoelectric point4.87
Protein length607 amino acids
Structural information
PFAMB2HKD3
Orthologs
M. tuberculosis H37RvRv3710
Cross-references
UniProtB2HKD3
Gene Ontology2-isopropylmalate synthase activity, Leucine biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
Functioninvolved in leucine biosynthesis (at the first step). catalyzes condensation of acetyl-CoA and 2-oxoisovalerate to form 2-isopropylmalate synthase [catalytic activity: 3-carboxy-3-hydroxy-4-methylpentanoate + CoA = acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O].
Product2-isopropylmalate synthase LeuA
Comments-
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS63153236317143+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium marinum M|MMAR_5225|leuA
VTNSSQAPGPDAFTSARTIVKPAGPPSPGQPVWNPQRASSMPVNRYRPFAEEVEHIRVTDRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLTQCRPELIERTFEACAGASKVIVHFYNSTSILQRRVVFRADRAAVQAIATEGARRCVEEAAKYPDTQWRFEYSPESYTGTELEYAKQVCDAVAEVIQPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVPERHPYGGDLVYTAFSGSHQDAINKGLDAMKFDADAADSDMDDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSRAIQEIAEGSAGEGGEVSPKEMWDAFAEEYLAPVRPLERIKQRVIAAEEDGGTTSIDATVKIDGKETEISGSGNGPLAAFVHALGSVGFDVAVLDYSEHAMSAGDDAQAAAYVEASVAGKTVWGVGIAPSITTASLRAVVSAINRASR
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