Gene MSMEG_1878
in Mycobacterium smegmatis MC2-155
General annotation
| Type | CDS |
| Function | Binds to the ribosomes at the decoding region of the 30S subunit, resulting in ribosome inactivation and tolerance to aminoglycosides. Binding to the ribosome is induced by zinc depletion. |
| Product | Mycobacterial-specific protein Y (MPY) |
| Comments | identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741. Shown to bind to the decoding region of the 30S subunit under zinc depleted condition. Referred to as mycobacterial-specific protein Y (MPY) (see Li et al. 1018). |
| Functional category | Unknown |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1955596 | 1956288 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium smegmatis MC2-155|MSMEG_1878|MSMEG_1878
MSSHSMDSSRTMVVEDDRESTAGTTPERPHAEVVVKGRNVEVPDHFRTYVSEKLSRLERFDKTIYLFDVELDHERNRRQRKNCQHVEITARGRGPVVRGEACADSFYTAFESAVQKLEGRLRRAKDRRKIHYGDKTPVSLAEATAKDPLAGLDVSREDGEARYNDGVAEHEPGRIVRIKDHPATPMTVDDALYEMELVGHDFFLFHDKETDRPSVVYRRHAFDYGLIRLA
Bibliography
- Li Y et al. [2018]. Zinc depletion induces ribosome hibernation in mycobacteria. Structure Function
- Li Y et al. [2018]. Zinc depletion induces ribosome hibernation in mycobacteria. Function
- Li Y et al. [2019]. Reply to Tobiasson et al.: Zinc depletion is a specific signal for induction of ribosome hibernation in mycobacteria. Function
