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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionAlpha-mannosidase activity: hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
ProductAlpha-mannosidase
CommentsRv0648, (MTCY20H10.29), len: 1215 aa. Alpha-mannosidase (see citation below), showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q55528 hypothetical 1 20.4 kDa protein from Synechocystis (1042 aa), FASTA scores: opt: 260, E(): 3.6e-08, (23.4% identity in 602 aa overlap); etc. Contains PS00659 Glycosyl hydrolases family 5 signature.
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005).
TranscriptomicsmRNA identified by RT-PCR (see citation below).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS742719746366+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv0648|Rv0648
VMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADAGLTSSSWARGPHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLLTHYMPAHYSAGWSMDSSTSLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPPNKWVTAIHRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPSPQTRDMNPIYTGKDVSYIDTKQANRAAENAVLEAERFAVFAALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRAARDNSLRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAEVAALVEHDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVDPERGGALSSLVQDGRQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTGPVVCSSACPAQVQAYRGPLGQRLVVRGRIGTLLRYTQTLTLWDGVDRVDCRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDAVVGRGFALLHEGPESVDTAQHPWTLDNPAYGWFGLSSAVRVRAGDGVRAVSVAEVVSPTETVSGPMARDLMVALVRAGVTATCSGADKPRYGHLDVDSNLPDARIALGGPDRNTFTKAVLAEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGADLRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQRAAPQMEPFEDRTVALLNRGVPSFAVDSEGTLHTALMRSCTGWPSGVWIDQPRRTAPDGSNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLAVAPRRPQGELPAVGSLLHVEPADSVQLGALKAAGNPLAAGSARPVQPAAVALRLVQTTGADTPVTIGCELGKVGALRPADLLETPLAMARARKSSIDLHGYQVATVLARLDVAADMANVLAADDVALAPHAETAQPQYARYWLHNRGPAPLGGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGGVVDVVCPLGWPATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDTAVPAAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGSRAHAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLEPGQWWALVRVGCAGQLVYSPAVKVSVT