Gene Rv1104
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | In combination with MTV017.58|Rv1105 catalyzes hydrolysis of several beta-lactam antibiotic PNB esters to the corresponding free acid and PNB alcohol |
| Product | Possible para-nitrobenzyl esterase (fragment) |
| Comments | Rv1104, (MTV017.57), len: 229 aa. Possible para-nitrobenzyl esterase (fragment; possibly first part) . Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA scores: opt: 715, E(): 0, (53.4% identity in 191 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing in MTV017.58|Rv1105. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1231301 | 1231990 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1104|Rv1104
MVVDSCVAESRYGPVRGADDGRVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTFGPACPQPAIPNMPLDLGASQSEDCWSLNIWAPADTEPGDGKPVMVWLHGGAYILGSGSQPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRRFDSNIGLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARESSRPCSPPRRPRVCSRRRSPRAHRRHRSTTR
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
