Gene Rv1200
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown; probably involved in transport accross the membrane (probably sugar transport). |
| Product | Probable conserved integral membrane transport protein |
| Comments | Rv1200, (MTCI364.12), len: 425 aa. Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. YHJE_ECOLI|P37643 hypothetical metabolite transport protein from Escherichia coli (440 aa), FASTA scores: opt: 1047, E(): 0, (39.1% identity in 427 aa overlap); etc. Contains PS00217 Sugar transport proteins signature 2. The transcription of this CDS seems to be activated in macrophages (see citation below). |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1342942 | 1344219 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1200|Rv1200
MKRVALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVAFLSRPFGAAVFGYFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGAAAPLILTTMRLLQGFAVGGEWAGSALLSAEYAPASKRGWYGMFTVVGGGIALVLTSLTFLGVNYTIGESSPTFMQWGWRIPFLVSAALIAVALYVRFNIDETPVFARERADEKTRLGPAETPIAQVLRRQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVMPLIDSGSPSLFAVAVVGMYAIGGFGFGPTASFIPELFATSYRYTGSALAANLAGVAGGALPPVIAGALVATYGSWAIGVMLAILALISLVCTYRLPETAGSALVSR
Bibliography
- Ramakrishnan L et al. [2000]. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Homolog Regulation
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
