Gene Rv1505c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv1505c, (MTCY277.27c), len: 221 aa. Conserved hypothetical protein, some similarity to hypothetical proteins and glycosylases e.g. P71063|O08181 hypothetical 22.5 kDa protein YVFD from Bacillus subtilis (216 aa), FASTA scores: E(): 2.4e-08, (25.5% identity in 196 aa overlap). |
| Functional category | Conserved hypotheticals |
| Proteomics | Translational start site supported by proteomics data (See Kelkar et al., 2011). |
| Transcriptomics | DNA microarrays show lower level of expression in M. tuberculosis H37Rv than in phoP|Rv0757 mutant (See Walters et al., 2006). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1695281 | 1695946 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1505c|Rv1505c
MTKPLVIFGSGDIAQLAHYYFTRDSEYEVVAFTVDRDYASVSEFCGLPLVAFDEVAQRFPPESHAMFVALAYAKLNGVRKEKYLAAKALGYELASYVSSHATVLNDGRIGENVFLLEDNTIQPFVSIGNNVTLWSGNHIGHHSTIHDHCFLASHIVVSGGVVIEEQSFIGVNATLRDHITIGSRCVVGAGALLLGDADADGVYIGTKTERRPVPSTELRKI
Bibliography
- Walters SB et al. [2006]. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Transcriptome
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- Kelkar DS et al. [2011]. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Proteomics Sequence
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
