Gene Rv1520
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown; thought to be involved in cellular metabolism. |
| Product | Probable sugar transferase |
| Comments | Rv1520, (MTCY19G5.08c), len: 346 aa. Probable sugar transferase, similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa), FASTA scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa overlap); O34234|Y07786 sugar transferase from Vibrio cholerae (337 aa), FASTA scores: opt: 214, E(): 8.4e-05, (25.9% identity in 212 aa overlap). Also strongly similar to Mycobacterium tuberculosis probable sugar transferase Rv1516c. Alternative nucleotide at position 1711627 (C->T; Y200Y) has been observed. |
| Functional category | Intermediary metabolism and respiration |
| Proteomics | Identified in the cell wall and cell membrane fractions of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1711028 | 1712068 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1520|Rv1520
VSIVSISYNQEEYIREALDGFAAQRTEFPVEVIIADDASTDATPRIIGEYAARYPQLFRPILRQTNIGVHANFKDVLSAARGEYLALCEGDDYWTDPLKLSKQVKYLDRHPETTVCFHPVRVIYEDGAKDSEFPPLSWRRDLSVDALLARNFIQTNSVVYRRQPSYDDIPANVMPIDWYLHVRHAVGGEIAMLPETMAVYRRHAHGIWHSAYTDRRKFWETRGHGMAATLEAMLDLVHGHREREAIVGEVSAWVLREIGKTPGRQGRALLLKSIADHPRMTMLSLQHRWAQTPWRRFKRRLSTELSSLAALAYATRRRALEGRDGGYRETTSPPTGRGRNVRGSHA
Bibliography
- Lamichhane G et al. [2003]. A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Mutant
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Mawuenyega KG et al. [2005]. Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Proteomics
- Prakash P et al. [2005]. Computational prediction and experimental verification of novel IdeR binding sites in the upstream sequences of Mycobacterium tuberculosis open reading frames. Regulon
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
