Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionThought to be involved in lipid metabolism.
ProductPossible acyltransferase PlsB1
CommentsRv1551, (MT1601, MTCY48.14c), len: 621 aa. Possible plsB1, acyltransferase, similar to PLSB_HAEIN|P44857 glycerol-3-phosphate acyltransferase from Haemophilus influenzae (810 aa), FASTA scores: opt: 434, E(): 6.2e-22, (27.6% identity in 395 aa overlap). Also similar to Rv2482c|plsB2 Probable glycerol-3-phosphate acyltransferase from Mycobacterium tuberculosis (789 aa).
Functional categoryLipid metabolism
ProteomicsIdentified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Translational start site supported by proteomics data (See Kelkar et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17554451757310+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1551|plsB1
VTAREVGRIGLRKLLQRIGIVAESMTPLATDPVEVTQLLDARWYDERLRALADELGRDPDSVRAEAAGYLREMAASLDERAVQAWRGFSRWLMRAYDVLVDEDQITQLRKLDRKATLAFAFSHRSYLDGMLLPEAILANRLSPALTFGGANLNFFPMGAWAKRTGAIFIRRQTKDIPVYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGILRYITDAVDEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLARQQGERLGRAYLDFGEPLPLRKRLQEMRADKSGTGSEIERIALDVEHRINRATPVTPTAVVSLALLGADRSLSISEVLATVRPLASYIAARNWAVAGAADLTNRSTIRWTLHQMVASGVVSVYDAGTEAVWGIGEDQHLVAAFYRNTAIHILVDRAVAELALLAAAETTTNGSVSPATVRDEALSLRDLLKFEFLFSGRAQFEKDLANEVLLIGSVVDTSKPAAAADVWRLLESADVLLAHLVLRPFLDAYHIVADRLAAHEDDSFDEEGFLAECLQVGKQWELQRNIASAESRSMELFKTALRLARHRELVDGADATDIAKRRQQFADEIATATRRVNTIAELARRQ