Gene Rv1645c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv1645c, (MTCY06H11.10c), len: 351 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53837|Rv0826|MTV043.18 (351 aa), FASTA scores: (57.5% identity in 299 aa overlap); Q10519|Rv2237|YM37_MYCTU (255 aa), O53682|Rv0276 (306 aa). |
| Functional category | Conserved hypotheticals |
| Transcriptomics | mRNA identified by microarray analysis; transcription repressed at low pH in vitro conditions, which may mimic an environmental signal encountered by phagocytosed bacteria (see citation below). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Disruption of this gene provides a growth advantage for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1854399 | 1855454 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1645c|Rv1645c
MTVASRTSADPLGPDSLTWKYFGDLRTGMMGVWIGAIQNMYPELGAGVEEHSILLREPLQRVARSVYPIMGVVYDGDRAAQTGQQIKGYHRTIKGVDAEGRRYHALNPDTFYWAHATFFMLVIKVAEYFCGGLTEAEKHQLFEEHVRWYRMYGMSMRPVPKSWEDFQDYWDRVCRDKLEINQATVDILQMRIPKPRFVLMPTPIWDQLFKPLIAGQRWIAAGLFDPAVREKAGMHWTPGDEVLLRVFGKVVELAFLAVPDEIRLHPRALAAYRRAAGRTRHDAPLVQAPGFMAPPRDRQGLPMHYFPPRSHRFTRSALDPAKALMERAGALVHSTLSLAGVRPARGPSRAA
Bibliography
- Fisher MA, Plikaytis BB and Shinnick TM [2002]. Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. Transcriptome Regulation
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- Mazandu GK et al. [2012]. Function prediction and analysis of mycobacterium tuberculosis hypothetical proteins. Function
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
