Gene Rv1902c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Involved in transport of sialic acid across the membrane. Responsible for the translocation of the substrate across the membrane. |
| Product | Probable sialic acid-transport integral membrane protein NanT |
| Comments | Rv1902c, (MTCY180.16), len: 422 aa. Probable nanT, sialic acid-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. Q48076 sialic acid transporter (407 aa), FASTA results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa overlap); etc. Some similarity to MTCI364.12|O05301 conserved hypothetical protein from Mycobacterium tuberculosis (425 aa), FASTA results: opt: 251, E(): 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar transport proteins signature 2 (PS00217). |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2149006 | 2150274 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1902c|nanT
VAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMNWLGLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQDVYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGKDATGIRFGTTETAFLVRHRNRH
Bibliography
- Lamichhane G et al. [2003]. A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Mutant
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
