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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionInvolved in transport of sialic acid across the membrane. Responsible for the translocation of the substrate across the membrane.
ProductProbable sialic acid-transport integral membrane protein NanT
CommentsRv1902c, (MTCY180.16), len: 422 aa. Probable nanT, sialic acid-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. Q48076 sialic acid transporter (407 aa), FASTA results: opt: 443, E(): 5.4e-22, (26.7% identity in 389 aa overlap); etc. Some similarity to MTCI364.12|O05301 conserved hypothetical protein from Mycobacterium tuberculosis (425 aa), FASTA results: opt: 251, E(): 1.1e-09, (23.5% identity in 417 aa overlap). Contains sugar transport proteins signature 2 (PS00217).
Functional categoryCell wall and cell processes
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21490062150274-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1902c|nanT
VAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMNWLGLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQDVYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGKDATGIRFGTTETAFLVRHRNRH