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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown, but thought to be involved in host cell invasion.
ProductMce-family protein Mce3C
CommentsRv1968, (MTV051.06), len: 410 aa. Mce3C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); etc. Also similar to others e.g. CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al., 2002). Predicted to be an outer membrane protein (See Song et al., 2008).
Functional categoryVirulence, detoxification, adaptation
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22116262212858+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1968|mce3C
MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYFADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEVAIKTKGLLGSKFLDVTPRGDGRLDSPIPIERTTSPYQLPDALGDLAATISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRSLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAVAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSLGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQLTDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDPRYPYRPEPPAPPPGGPPPGPPAQQPGDQP