Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductConserved hypothetical protein
CommentsRv2143, (MTCY270.25c), len: 352 aa. Conserved hypothetical protein, strongly similar to two hypothetical mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from position 120 (Q50819; Q50111). FASTA best: Q50819 opt: 882, E() 0; (61.1% identity in 226 aa overlap). Also similar to AL021942|MTV039_9 (443 aa), FASTA scores: opt: 592, E(): 5e-30; 46.9% identity in 224 aa overlap
Functional categoryConserved hypotheticals
ProteomicsIdentified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Disruption of this gene provides a growth advantage for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24029772404035+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2143|Rv2143
MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENESLLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRDRLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQRRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIRATGPESIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT