Gene Rv2690c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable conserved integral membrane alanine and valine and leucine rich protein |
| Comments | Rv2690c, (MTCY05A6.11c), len: 657 aa. Probable conserved integral membrane ala-, val-, leu-rich protein, highly similar to others e.g. O54098|SC10A5.05 putative membrane protein from Streptomyces coelicolor (691 aa), FASTA scores: opt: 2007, E(): 1.6e-116, (62.35% identity in 669 aa overlap); O69917|SC3C8.04c putative integral membrane protein from Streptomyces coelicolor (644 aa), FASTA scores: opt: 923, E(): 1.7e-49, (35.3% identity in 669 aa overlap); AAK78253|CAC0272 amino acid transporter from Clostridium acetobutylicum (620 aa), FASTA scores: opt: 674, E(): 4.1e-34, (36.55% identity in 640 aa overlap); etc. |
| Functional category | Cell wall and cell processes |
| Proteomics | Identified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010). |
| Mutant | Essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3007236 | 3009209 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2690c|Rv2690c
VSKLSTAARRLLIGRPFRSDRLSHTLLPKRIALPVFASDAMSSIAYAPEEIFLVLSVAGLAAYSMAPLIGLAVAAVLLVVVSSYRQNVHAYPSGGGDYEVVTTNLGATGGLVVASALMVDYVLTVAVSISSAASNIGSVSPFVYEHKVLFAVGAIVLIMAMNLRGVRESGLAFAIPTYAFIAGIGTMLVWGLFRIFVLGNPVRAESAAFEMHAEHGQIVGFALVFLVARSFSSGCAALTGVEAISNGVPAFQKPKSRNAATTLLMLGIIAVSMFMGMIVLAVETGVQVVDDPDTQLTGAPPGYQQKTLVAQLAQAVFGGFYLGFLLIAAVTALILVLAANTAFNGFPVLGSVLAQHSYLPRQLHTRGDRLAFSNGILFLAAAAIGAVVAFRAELTALIQLYIVGVFISFTMSQVGMVRHWTRLLSAETDPRARRAMLRSRAVNTVGFVSTGTVLLIVLVTKFLAGAWIAIVAMGGFFMMMKLIHRHYDAVNRELAEQAEEAEITLPSRNHAVVLVSKLHLPTLRALTYARATRPDVLEAVTVNVDDAETRELVRQWQDSDVSVPLKVIASPYREITRPVLDYVKRVSKESPRTVVTVFIPEYVVGRWWEQLLHNQSALRLKGRLLFMPGVMVTSVPWQLTSSERIKTLQPHAAPGDT
Bibliography
- Mawuenyega KG et al. [2005]. Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Proteomics
- Kruh NA et al. [2010]. Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. Proteomics
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
