Gene Rv2729c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable conserved integral membrane alanine valine and leucine rich protein |
| Comments | Rv2729c, (MTCY154.09c), len: 301 aa. Probable conserved integral membrane ala-, val-, leu-rich protein, similar to P42459|YLEU_CORGL hypothetical 29.6 KDA protein from Corynebacterium glutamicum (Brevibacterium flavum)(270 aa), FASTA scores: opt: 365, E(): 4.7e-15, (30.75% identity in 221 aa overlap); and to other integral membrane proteins (principally from Streptomyces sp.) e.g. Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa), FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in 278 aa overlap); Q9S267|SCI30A.06 from Streptomyces coelicolor (297 aa), FASTA scores: opt: 356, E(): 1.8e-14, (31.5% identity in 289 aa overlap); AAK81278|CAC3346 from Clostridium acetobutylicum (472 aa), FASTA scores: opt: 154, E(): 0.038, (24.1% identity in 224 aa overlap); etc. |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3041570 | 3042475 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2729c|Rv2729c
MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLFHLSLRHALWWLGSLAAVASFTLQAIALTMGSVVLVQSLQATALLFALLIDARLTHHRCTPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFSTWAVVAVVVVPAVVLCVVGARIASGSLSAVLLAVASSATLAVFTVLTKGVVTELGEGFATLIRTPALYAWILVLPIGLMLQQSSLRVGALTASLPTITVARPVIASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVALARDEVAMMTVSAGELGAAGQLAVR
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
