Gene Rv2739c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown; probably involved in cellular metabolism. |
| Product | Possible alanine rich transferase |
| Comments | Rv2739c, (MTV002.04c), len: 388 aa. Possible ala-rich transferase, equivalent to Q49841|ML0985|MLCB33.02c|U2235C possible glycosyltransferase from Mycobacterium leprae (392 aa), FASTA scores: opt: 2112, E(): 5.1e-114, (80.95% identity in 388 aa overlap). Shows some similarity with other transferases e.g. Q9S1V2|SCJ4.21 putative glycosyl transferase from Streptomyces coelicolor (407 aa), FASTA scores: opt: 290, E(): 2e-09, (27.75% identity in 382 aa overlap); Q9RYI3|DRA0329 putative glycosyltransferase from Deinococcus radiodurans (418 aa), FASTA scores: opt: 267, E(): 4.3e-08, (29.05% identity in 396 aa overlap); P96560|GTFC glycosyltransferase from Amycolatopsis orientalis (409 aa), FASTA scores: opt: 253, E(): 2.7e-07, (27.75% identity in 418 aa overlap); etc. Equivalent to AAK47130 from Mycobacterium tuberculosis strain CDC1551 (420 aa) but shorter 32 aa. |
| Functional category | Intermediary metabolism and respiration |
| Proteomics | Identified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3052023 | 3053189 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2739c|Rv2739c
MRVAVVAGPDPGHSFPAIALCQRFRAAADTPTLFTGVEWLEAARAAGIDAVELDGLAATDRDLDAGARIHRRAAQMAVLNVPRLRALEPELVVSDVITACGGMAAELLGIPWVELNPHPLYLPSKGLPPIGSGLAAGTGIRGRLRDATMRALTGRSWRAGLRQRAAVRVEIGLPARDPGPLRRLIATLPALEVPRPDWPAEAVVVGPLHFEPTDRVLAIPAGTGPVVVVAPSTALTGTAGLTEVALQSLTPGETVPSGSRLVVSRLSGADLTVPPWAVAGLGSQAELLTRADLVICGGGHGMVAKTLLAGVPMVVVPGGGDQWEIANRVVRQGSAVLIRPLTADALVAAVNEVLSSPRFREAARRAAASVAGAADPVRVCHDALALAG
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- de Souza GA et al. [2011]. Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway. Proteomics
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
