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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductConserved protein
CommentsRv2751, (MTV002.16), len: 296 aa. Conserved protein, similar in part to others e.g. Q98LR1|MLR0915 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (299 aa), FASTA scores: opt: 279, E(): 1.6e-11, (32.85% identity in 210 aa overlap); Q9FBX1|SC8E7.10 conserved hypothetical protein from Streptomyces coelicolor (283 aa), FASTA scores: opt: 232, E(): 2.4e-08, (27.9% identity in 269 aa overlap); Q9FMY9 hypothetical protein (genomic DNA, chromosome 5, P1 clone:MJB21) from Arabidopsis thaliana (Mouse-ear cress) (370 aa), FASTA scores: opt: 205, E(): 2.1e-06, (28.9% identity in 211 aa overlap); etc. Also similar in part to several proteins from Mycobacterium tuberculosis: P72053|Rv3787c|MTCY13D12.21 hypothetical 33.4 KDA protein (308 aa), FASTA scores: opt: 266, E(): 1.3e-10, (29.6% identity in 267 aa overlap); O53795|MBE50c|Rv0731c|MTV041.05c hypothetical 34.9 KDA protein (318 aa), FASTA scores: opt: 266, E(): 1.3e-10, (32.05% identity in 281 aa overlap); O53841|Rv0830|MTV043.22 hypothetical 33.4 KDA protein (301 aa), FASTA scores: opt: 263, E(): 2e-10, (31.3% identity in 262 aa overlap); etc. Belongs to the MTCY13D12.21 / MTCY210.45C / MTCY78.29C family.
Functional categoryConserved hypotheticals
ProteomicsIdentified in the membrane fraction of M. tuberculosis H37Rv using 1D-SDS-PAGE and uLC-MS/MS (See Gu et al., 2003). Identified in the membrane fraction of M. tuberculosis H37Rv using nanoLC-MS/MS (See Xiong et al., 2005). Identified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS30636383064528+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2751|Rv2751
MARNPAAQTAFGPMVLAAVEQNEPPGRRLVDDDLADLFLPRPLRWLAGATRSAVLRRLLISASEWSGRGLWANLACRKRFIGDKLDEALGDIDAVVILGAGLDTRAYRLTRRVRMPVFEVDLPVNIARKAKTVRRVLGELPLSVRLVALDFEHDDLLTALAEHGYRTEYRVFFVCEGVTQYLTERAVRRTLEGLRAAAPGSRMVFTYVRRDFIDGTNRYGTRTLYHTVRQRRQLWHFGLDPEEVAGFLADYGWRLTEQAGPEELVQRYVEPTGRNLNASQIEWSAYAEKSEPVTPR