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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductPE-PGRS family protein PE_PGRS48
CommentsRv2853, (MTCY24A1.04c), len: 615 aa. PE_PGRS48, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many e.g. O53884|Rv0872c|MTV043.65c from Mycobacterium tuberculosis (606 aa), FASTA scores: opt: 1405, E(): 1.4e-97, (64.6% identity in 619 aa overlap). Equivalent to AAK47245 from Mycobacterium tuberculosis strain CDC1551 (663 aa) but shorter 48 aa.
Functional categoryPe/ppe
ProteomicsIdentified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 and 90 days (See Kruh et al., 2010).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS31622683164115+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2853|PE_PGRS48
MLYVVASPDLMTAAATNLAEIGSAISTANGAAALPTVEVVAAAADEVSTQIAALFGAHARSYQTLSTQAAAFHSRFVQALTTAAASYASVEAANASPLQVALDVINAPAQTLLGRPLIGNGADGSTPGQAGGPGGLLYGNGGNGAAGGPNQAGGAGGNAGLIGNGGAGGAGGVGAVGGKRGTGGLLFGNGGAGGQGGLGLAGINGGSGGQGGHGGNAILFGQGGAGGPGGTGAMGVAGTNPTPIGTAAPGSDGVNQIGNGGNTDLTGGAGGDGNAGSTTVNGGNGGTGGAARNSSGGTGNSFGGAGGAGGDGANGGDGGAGGEALTEGGATAVSGAGGKGGNAEASGGAGGNGGKGGFAQATTSVTGGNGGNGGNGHDSNAPGGAGGSGGVGGDGGRGGLLAGNGGTGGAGGNGGTGGAGAPGGAGGAGGKADIANSLGDNATVTGGNGGTGGDGGSALGTGGAGGAGGLGGHGGAGGLLIGNGGAGGAGGLGGAGGAGGAGGEGGAGGAGGEAIPGGASTNSAGGDGGAGGTGGNGGDGGAGGAPGLGGAGGAGGWLIGQSGSTGGGGAGGAGGAGGAGGAGGSGGAGGHGDTTSGKNGSSGTAGFDGNPGQPG