Gene Rv2899c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Necessary for formate dehydrogenase activity |
| Product | Possible FdhD protein homolog |
| Comments | Rv2899c, (MTCY274.30c), len: 276 aa. Possible fdhD protein homolog, highly similar to other bacterial fdhd protein homologs or formate dehydrogenase accessory proteins e.g. Q9ZBW0|FDHD_STRCO|SC4B5.08c from Streptomyces coelicolor (282 aa), FASTA scores: opt: 1032, E(): 3.6e-59, (59.0% identity in 278 aa overlap); BAB59387|TVG0258796 from Thermoplasma volcanium (279 aa), FASTA scores: opt: 536, E(): 3.4e-27, (38.65% identity in 282 aa overlap); Q9HL17|FDHD_THEAC|TA0423 from Thermoplasma acidophilum (282 aa), FASTA scores: opt: 529, E(): 9.6e-27, (38.8% identity in 281 aa overlap); P32177|FDHD_ECOLI FDHD protein from Escherichia coli strain K12 (277 aa), FASTA scores: opt: 297, E(): 8.6e-12, (33.35% identity in 261 aa overlap); etc. Contain a Pfam match to entry PF02634 FdhD/NarQ family. Belongs to the FdhD family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3208576 | 3209406 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2899c|fdhD
VGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
