Gene Rv2915c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved protein |
| Comments | Rv2915c, (MTCY338.03c), len: 370 aa. Conserved protein, posssibly XAA-pro dipeptidase (prolidase), highly similar to CAC38796|SCI39.08c conserved hypothetical protein from Streptomyces coelicolor (363 aa), FASTA scores: opt: 1341, E(): 5.5e-76, (56.65% identity in 362 aa overlap); and similar to prolidases (XAA-pro dipeptidase) e.g. Q9ABC9|CC0300 putative XAA-pro dipeptidase from Caulobacter crescentus (428 aa), FASTA scores: opt: 327, E(): 7.4e-13, (30.2% identity in 374 aa overlap); Q97XD4 prolidase from Sulfolobus solfataricus (396 aa), FASTA scores: opt: 271, E(): 2.1e-09, (30.5% identity in 354 aa overlap); Q9WX55 prolidase from Microbacterium esteraromaticum (393 aa), FASTA scores: opt: 256, E(): 1.8e-08, (27.95% identity in 365 aa overlap); etc. Also similar to O53619|Rv0074|MTV030.18 conserved hypothetical protein from Mycobacterium tuberculosis (411 aa), FASTA scores: opt: 243, E(): 1.2e-07, (27.5% identity in 389 aa overlap). |
| Functional category | Conserved hypotheticals |
| Proteomics | Identified by mass spectrometry in Triton X-114 extracts of M. tuberculosis H37Rv (See Malen et al., 2010). Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010). Identified by mass spectrometry in the membrane protein fraction of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011). |
| Mutant | Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3223568 | 3224680 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2915c|Rv2915c
VKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAGADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTRGLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDWIDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLTDDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAGVPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASADLLCYAQDPRQGPGVLQHPDLVILRGRTFGP
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Kruh NA et al. [2010]. Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. Proteomics
- Målen H et al. [2010]. Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv. Proteomics
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- de Souza GA et al. [2011]. Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway. Proteomics
- Mazandu GK et al. [2012]. Function prediction and analysis of mycobacterium tuberculosis hypothetical proteins. Function
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
