Gene Rv3070
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable conserved integral membrane protein |
| Comments | Rv3070, (MTCY22D7.11c), len: 126 aa. Probable conserved integral membrane protein, similar to several hypothetical and CRCB bacterial proteins e.g. Q9FC37|SC4G1.12 putative integral membrane protein from Streptomyces coelicolor (124 aa), FASTA scores: opt: 280, E(): 3.1e-11, (45.3% identity in 117 aa overlap); O25823|HP1225 conserved hypothetical integral membrane protein from Helicobacter pylori (Campylobacter pylori) (130 aa), FASTA scores: opt: 225, E(): 1e-07, (33.35% identity in 123 aa overlap); O07590|YHDU hypothetical 12.4 KDA protein from Bacillus subtilis (118 aa), FASTA scores: opt: 224, E(): 1.1e-07, (37.85% identity in 111 aa overlap); Q9KVS9|VC0060 CRCB protein (see Hu et al., 1996; seems involved in camphor resistance and chromosome condensation, promoting or protecting chromosome folding) from Vibrio cholera (126 aa), FASTA scores: opt: 221, E(): 1.8e-07, (33.35% identity in 126 aa overlap); etc. |
| Functional category | Cell wall and cell processes |
| Transcriptomics | mRNA identified by SCOTS method, 48h and 110h after infection of cultured human primary macrophages (see Graham & Clark-Curtiss 1999). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3434087 | 3434467 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3070|Rv3070
MTASTALTVAIWIGVMLIGGIGSVLRFLVDRSVARRLARTFPYGTLTVNITGAALLGFLAGLALPKDAALLAGTGFVGAYTTFSTWMLETQRLGEDRQMVSALANIVVSVVLGLAAALLGQWIAQI
Bibliography
- Hu KH et al. [1996]. Overproduction of three genes leads to camphor resistance and chromosome condensation in Escherichia coli. Secondary Homolog Function
- Graham JE and Clark-Curtiss JE [1999]. Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Transcriptome
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
