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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPossible antitoxin VapB46
CommentsRv3385c, (MTV004.43c), len: 102 aa. Possible vapB46, antitoxin, part of toxin-antitoxin (TA) operon with Rv3386c, see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis hypothetical proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa), FASTA scores: opt: 155, E(): 0.001, (41.05% identity in 78 aa overlap); O07782|Rv0596c|MTCY19H5.26 (85 aa), FASTA scores: opt: 136, E(): 0.016, (39.45% identity in 71 aa overlap); P96916|Rv0626|MTCY20H10.07 (86 aa), FASTA scores: opt: 130, E(): 0.04, (51.2% identity in 41 aa overlap); etc. Also similar to prevent host death (PHD) proteins e.g. CAA66834|PHD from Escherichia coli (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap).
Functional categoryVirulence, detoxification, adaptation
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37996353799943-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3385c|vapB46
MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPSVTLARLREHER