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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown; probably involved in cellular metabolism.
ProductPossible hydrolase
CommentsRv3591c, (MTCY6F7.03), len: 257 aa. Possible hydrolase, equivalent to Q9CBI9|ML1921 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421, E(): 5.6e-83, (78.5% identity in 251 aa overlap). Also similar to others e.g. Q9K3V0|SCD10.27 putative hydrolase from Streptomyces coelicolor (352 aa), FASTA scores: opt: 193, E(): 5.2e-05, (33.35% identity in 270 aa overlap); O33745|STTC thioesterase from Streptomyces sp (308 aa) FASTA scores: opt: 242, E(): 3.6e-08, (30.35% identity in 270 aa overlap); Q9RK95|SCF1.09 putative hydrolase from Streptomyces coelicolor (258 aa), FASTA scores: opt: 239, E(): 4.9e-08, (30.75% identity in 247 aa overlap); Q9HZ14|PA3226 probable hydrolase from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 226, E(): 3.4e-07, (26.6% identity in 252 aa overlap); Q9HPT9|est|VNG1474G carboxylesterase from Halobacterium sp. strain NRC-1 (274 aa), FASTA scores: opt: 215, E(): 1.7e-06, (26.95% identity in 256 aa overlap); etc.
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified by mass spectrometry in Triton X-114 extracts of M. tuberculosis H37Rv (See Malen et al., 2010). Identified by mass spectrometry in the membrane protein fraction and whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS40332694034042-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3591c|Rv3591c
VPRMPANLLTHRGGRGEPLVLVHGLMGRGSTWARQLPWLTLLGAVYTYDAPWHRGRDVADPHPISTERFVADLGDAVSALGAPTRMVGHSMGALHSWCLAAERPELVSALVVEDMAPDFRGRTTGPWEPWLRALPVEFDSAEQVFAEFGPVAGRYFLDAFDRTATGWRLHGRTARWIEIAAEWGTRDYWAQWRAVRSPALLIEAGDGVTPPGQMRAMAERDYPTAYLRVPDAGHLVHDEAPQVYRRAVESFLAGLTP