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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductProbable conserved integral membrane protein
CommentsRv3630, (MTCY15C10.22c), len: 431 aa. Probable conserved integral membrane, highly similar to P71789|YF10_MYCTU|Rv1510|MTCY277.32 hypothetical 44.3 KDA protein from Mycobacterium tuberculosis (432 aa) FASTA scores: opt: 1940, E(): 2.3e-103, (70.75% identity in 424 aa overlap). Note that N-terminal end is highly similar to AAK45825|MT1558 hypothetical 18.1 KDA protein from Mycobacterium tuberculosis strain CDC1551 (172 aa) FASTA scores: opt: 649, E(): 4.2e-30, (61.65% identity in 167 aa overlap); and C-terminal end is highly similar to AAK45826|MT1560 hypothetical 25.8 KDA protein from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 1269, E(): 2.6e-65, (76.7% identity in 253 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site, so could be a protease.
Functional categoryCell wall and cell processes
ProteomicsIdentified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS40691754070470+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3630|Rv3630
LAVGAAAVTEVGDTASPVGSSGASGGAIASGSVARVGTAAAVTALCGYAVIYLAARNLAPNGFSVFGVFWGAFGLVTGAANGLLQETTREVRSLGYLDVSADGRRTHPLRVSGMVGLGSLVVIAGSSPLWSGRVFAEARWLSVALLSIGLAGFCLHATLLGMLAGTNRWTQYGALMVADAVIRVVVAAATFVIGWQLVGFIWATVAGSVAWLIMLMTSPPTRAAARLMTPGATATFLRGAAHSIIAAGASAILVMGFPVLLKLTSNELGAQGGVVILAVTLTRAPLLVPLTAMQGNLIAHFVDERTERIRALIAPAALIGGVGAVGMLAAGVVGPWIMRVAFGSEYQSSSALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYSLGWVGATVGSGLLLLLPLSLETRTVVALLCGPLVGIGVHLVALARTDE