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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown; probably involved in cellular metabolism.
ProductPossible acyltransferase
CommentsRv3815c, (MTCY409.15), len: 251 aa. Possible acyltransferase, highly similar to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa), FASTA scores: opt: 845, E(): 2.7e-47, (53.25% identity in 246 aa overlap). Also highly similar to Q9K3R3|2SCG4.01 putative acyltransferase from Streptomyces coelicolor (242 aa), FASTA scores: opt: 656, E(): 3.7e-35, (47.85% identity in 234 aa overlap); and similar to many putative acyltransferases and hypothetical proteins e.g. P74498|SLL1848 hypothetical 24.3 KDA protein from Synechocystis sp. strain PCC 6803 (225 aa) FASTA scores: opt: 275, E(): 1.2e-10, (34.8% identity in 181 aa overlap); Q9ZBS1|SC7A1.02 putative acyltransferase from Streptomyces coelicolor (264 aa), FASTA scores: opt: 266, E(): 5.2e-10, (29.7% identity in 229 aa overlap); Q9PNZ5|AAS|CJ0938 putative 2-acylglycerophosphoethanolamine acyltransferase/ acyl-acyl carrier protein synthetase from Campylobacter jejuni (1170 aa), FASTA scores: opt: 264, E(): 2.3e-09, (23.55% identity in 221 aa overlap) (similarity only with middle section); etc. Also highly similar to upstream ORF O07809|Rv3814c|MTCY409.16 putative acyltransferase from Mycobacterium tuberculosis (261 aa), FASTA scores: opt: 1069, E(): 1e-61, (60.4% identity in 245 aa overlap) ; and downstream ORF O07807|Rv3816c|MTCY409.14 putative acyltransferase from Mycobacterium tuberculosis (259 aa) FASTA scores: opt: 847, E(): 2e-47, (55.7% identity in 246 aa overlap). And similar to O53516|Rv2182c|MTV021.15c hypothetical 27.0 KDA protein from Mycobacterium tuberculosis (247 aa), FASTA scores: opt: 237, E(): 3.6e-08, (30.9% identity in 233 aa overlap).
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS42800334280788-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3815c|Rv3815c
MAEPTYRVLEILAQLLVLATGTRITYVGEENVPDQGGAVVAINHTSYVDWLPAALAMHRRRRRMRFMIKAEMQRVRLVNFLIRHTRTIPVDRGAGGSAYAVAVQRLREGELVGVYPEATISRSFELKGFKTGAARMAAEADVPIVPVVVWGAQRIWTKDHPRQIGRAKVPVTVQVGRPLRAAAGIEQTNAALRESMTALLWQAQERYPHPAGAYWVPRRLGGGAPTLAEAARMEADEAAARAASRTPHESR