Gene Rv3836
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv3836, (MTCY01A6.33c), len: 137 aa. Conserved hypothetical protein, highly similar to Q9RKJ2|SCD25.30 hypothetical 13.1 KDA protein from Streptomyces coelicolor (116 aa), FASTA scores: opt: 395, E(): 3.3e-19, (54.4% identity in 114 aa overlap); and similar to CAC47753|SMC0379 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194, E(): 6e-06, (33.05% identity in 109 aa overlap); and Q98E37|MLL4425 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 184, E(): 3.7e-05, (29.75% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. |
| Functional category | Conserved hypotheticals |
| Transcriptomics | mRNA identified by microarray analysis and down-regulated after 96h of starvation (see citation below). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 4310401 | 4310814 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3836|Rv3836
VTVRMDPQRFDELVSDALDLIPPELADAMDNVVVLVANRHPQHENLLGQYEGVALTERGSDYAGSLPDAITIYREALLDACDSEDEVVDQVAITVIHEVAHHFGIDDERLDQLGWRDEPAPGRGNPDLSAPDAMNGP
Bibliography
- Betts JC et al. [2002]. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Transcriptome
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
