Gene ML0002
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | DNA polymerase III ia a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonucleases activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA [Catalytic activity: N deoxynucleoside triphosphate = N diphosphate + {DNA}N]. |
| Product | Probable DNA polymerase III, [beta] subunit DnaN |
| Comments | ML0002, len: 399 aa. Probable dnaN, DNA polymerase III (beta chain) (EC 2.7.7.7) (see citations below). Equivalent to other Mycobacterial DNA POLYMERASES III BETA CHAIN e.g. Rv0002|DP3B_MYCTU|Q50790 from M. tuberculosis (402 aa), Fasta scores: E(): 0, (81.9% identity in 403 aa overlap); and DP3B_MYCSM|P52851 from M. smegmatis (397 aa), Fasta scores: E(): 0, (77.3% identity in 397 aa overlap). Previously sequenced as DP3B_MYCLE|P46387 (399 aa), Fasta scores: E(): 0, (100.0% identity in 399 aa overlap). Contains Pfam match to entry PF00712 DNA_pol3_beta, DNA polymerase III beta subunit. |
| Functional category | Information pathways |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2081 | 3280 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0002|dnaN
MDLAKTNVGCSDLKFCLARESFASAVSWVAKYLPTRPTVPVLSGVLLTGSDSGLTISGFDYEVSAEVQVAAEIASSGSVLVSGRLLSDITRALPNKPVHFYVDGNRVALTCGSARFSLPTMAVEDYPTLPTLPDETGTLPSDVFAEAIGQVAIAAGRDYTLPMLTGIRIEISGDTVVLAATDRFRLAVRELKWSVLSSDFEASVLVPAKTLVEVAKAGTDGSGVCLSLGAGVGVGKDGLFGISGGGKRSTTRLLDAEFPKFRQLLPAEHTAVATIDVAELTEAIKLVALVADRGAQVRMEFGDGILRLSAGADDVGRAEEDLAVAFTGEPLTIAFNPNYLTDGLASVHSERVSFGFTTPSKPALLRPTSNDDVHPTHDGPFPALPTDYVYLLMPVRLPG
Bibliography
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