Gene ML0005
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | DNA Gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. This DNA Gyrase is made up of two chains. The A chain is responsible for DNA breakage and rejoining and the B chain catalyzes ATP hydrolysis [Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA]. |
| Product | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) |
| Comments | ML0005, len: 678 aa. Probable gyrB, DNA gyrase subunit B (EC 5.99.1.3) (see citations below). Highly similar to other Mycobacterial DNA GYRASES SUBUNIT B e.g. Rv0005|GYRB_MYCTU|P41514 from M. tuberculosis (686 aa), Fasta scores: E(): 0, (87.5% identity in 678 aa overlap); and GYRB_MYCSM|P48355 from Mycobacterium smegmatis (675 aa), Fasta scores: E(): 0, (85.0% identity in 678 aa overlap). Previously sequenced as GYRB_MYCLE|Q59533 (697 aa), Fasta scores: E(): 0, (100.0% identity in 678 aa overlap). Contains Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus. Contains Pfam match to entry PF00204 DNA_topoisoII, DNA topoisomerase II (N-terminal region). Contains PS00177 DNA topoisomerase II signature. Belongs to the type II Topoisomerase family. |
| Functional category | Information pathways |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 5229 | 7265 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0005|gyrB
VAAQRKAQDEYGAASITILEGLEAVRKRPGMYVGSTGERGLHHLIWEVVDNSVDEAMAGYATQVDVRLFDDGSVEVADNGRGIPVAVHATGVPTVDVVMTQLHAGGKFGGKDSGYNVSGGLHGVGVSVVNALSTRVEVDIKRDGYEWSQFYDKAVPGILKQGEATEATGTTIRFWADPDIFETTKYDFGTVARRIQEVAFLNKGLTINLVDERVKQDEVVDDVVSDTAEAPVAMTVEEKSTESSAPHKVRHRTFHYPGGLVDFVKHINRTKTPIQQSIIDFDGKGAGHEVEVAMQWNGGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQRVCNEQLIHWFEANPVDAKAVVNKAISSAQARIAARKARELVRRKSATDLGGLPGKLADCRSTDPRSSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDISRLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIEHGYVFLAQPPLYKLKWQRMDPEFAYSDSERDGLLETGLKLGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
Bibliography
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