Gene ML0011 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppiA
Gene length549 bp
IdentifierML0011
Location 15993 bp
Protein summary information
Molecular mass19367.4 Da
Isoelectric point5.84
Protein length183 amino acids
Structural information
PFAMPF00160
Orthologs
M. tuberculosis H37RvRv0009
M. lepromatosis Mx1-22AMLPM_0011
Cross-references
UniProtQ9CDE9
Gene OntologyPeptidyl-prolyl cis-trans isomerase activity, Protein folding, Cytoplasm
Enzyme Classification5.2.1.8
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A) (Rotamase A)
CommentsML0011, len: 182 aa. Probable ppiA, peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8)(see citations below), similar to Rv0009|CYPA_MYCTU|P71578 ppiA from M. tuberculosis (182 aa), Fasta scores: E(): 0, (90.1% identity in 182 aa overlap) and P77949|U64692 ScCypB peptidyl-prolyl cis-trans isomerase B from Streptomyces chrysomallus (175 aa), Fasta scores: E(): 0, (63.3% identity in 166 aa overlap). Also similar to ML0492 from M. leprae. Contains Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase. Belongs to the cyclophilin-type PPIase family.
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS1599316541+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0011|ppiA
MAHCDFVTNSLIQNATATLHTNRGDIKVALFGNHVPKTVANFVGLAQGTKEYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGETPHLNRRHTIFGEVTDPDSQKVVDAISTTATDGNDRPTEPVVIDSITIS
Bibliography
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