Gene ML0015
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Possibly involved in biosynthesis of tryptophan (at the first step). Thought to be a tetramer of two components I and two components II: component I (ML1269/trpE) catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II (ML0015/trpG) provides glutamine aminotranferase activity. Possibly participates in the tryptophan-dependent indole-3-acetic acid production [Catalytic activity: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate]. |
| Product | Possible anthranilate synthase component II TrpG (glutamine amidotransferase) |
| Comments | ML0015, len: 232 aa. Possible trpG, anthranilate synthase component II (glutamine amidotransferase) (EC 4.1.3.27), equivalent to Rv0013|Q50183|Z70722 possible trpG, anthranilate synthase component II from M. tuberculosis (232 aa), Fasta scores: E(): 0, (100.0% identity in 232 aa overlap); and similar to others e.g. TRPG_AZOBR|P26922 trpG from Azospirillum brasilense (196 aa), Fasta scores: E(): 0, (56.1% identity in 187 aa overlap). Previously sequenced as Q50183. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. Similarity to other type-1 glutamine aminotransferase domains. Note that previously known as pabA. |
| Functional category | Intermediary metabolism and respiration |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 18325 | 19023 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0015|trpG
MRILVIDNYDSFVFNLVQYLGQLGVDAEVWRNDDTRLSDESTIAAQFDGILLSPGPGTPERAGASINLVRVCAAAHTPLLGVCLGHQAIGVSFGATVDRAPELLHGKTSSVFHTNNGVLQGLPNPFTATRYHSLTILPESLPPVLEVVARTRSGVIMAVRHTELPIHGVQFHPESILTEGGHRLLANWLTYCGWLCDDALIRRLENEVDAAVHPRLPVAAERTAAAIARTLA
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