Gene ML0032 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameleuS
Gene length2919 bp
IdentifierML0032
Location 36321 bp
Protein summary information
Molecular mass108376.0 Da
Isoelectric point5.0
Protein length973 amino acids
Structural information
PFAMPF08264, PF09334
Orthologs
M. tuberculosis H37RvRv0041
M. lepromatosis Mx1-22AMLPM_0032
Cross-references
UniProtQ50192
Gene OntologyCytoplasm, Leucine-trna ligase activity, Leucyl-trna aminoacylation, Atp binding
Enzyme Classification6.1.1.4
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable leucyl-tRNA synthetase LeuS (Leucine--tRNA ligase)
CommentsML0032, len: 972 aa. Probable leuS, leucyl-tRNA synthetase (EC 6.1.1.4), highly similar to Rv0041|SYL_MYCTU|P71698 leuS, leucyl-tRNA synthetase from M. tuberculosis (969 aa), Fasta scores: E(): 0, (83.6% identity in 972 aa overlap) and similar to SYL_BACSU|P36430 leuS, leucyl-tRNA synthetase from Bacillus subtilis (804 aa), Fasta scores: E(): 0, (45.7% identity in 941 aa overlap). Previously sequenced as SYL_MYCLE|Q50192 (972 aa), Fasta scores: E(): 0, (99.9% identity in 972 aa overlap). Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to the class-I aminoacyl-tRNA synthetase family.
Functional categoryInformation pathways
Coordinates
TypeStartEndOrientation
CDS3632139239+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0032|leuS
VTELPTTVPGYNSAVAQTDSDAMRYRYTAELAGRIESTWQDNWARLQTFNVPNPVGSLAPPDGSVVPADKLFVQDMFPYPSGDGLHVGHPLGYIATDVYARYFRMTGHNVLHAMGFDAFGLPAEQYAMQTGTHPRILTEANVVNFRHQLGRLGLGHDSRRTFSTTDVEFYKWTQWIFLQIYNAWFDVAANKARPIAELIAEFDSGERRLVDGRDWATLSAGERADVIDNCRLVYRADSMVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDLLDWPEQVKTMQRNWIGRSSGATVLFSAILSRSDAATTEVDVEVFTTRPDTMFGVTYLVLAPEHNLVDELVATVWPDRTDPRWTYGAATPGAAVAAYRRAIVAKSDLDRQESKEKTGVFLGRYATNPATGKPVPIFVADYVLVGYGTGAVMAVPGHDPRDWDFAHKFHLPIVEVIAGSDISEAAYVGDGVLVNSGYLDGMDVATAQEAITARLESEGRGHARIEFKLRDWLFARQRYWGEPFPIIYDSDGRPHALDEAALPVELPDVPYYSPVLFDPDDADSEPSPPLAKATEWVHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERLCAKENEAYWMGPRPTEHGIDDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRRLINQGYIQAFAYTDAHGSYVPANQVFQRGDGFFCPGPDGEIEVFQEFGKIGKSLKNSVSPDEICDEYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVVDERTGETRVVDTAGELDTYTLRTLHRTIAGVSQDYAALRNNTATAKLIEYTNHLTKEHRGSVPRVAVEPLVLMLAPLAPHLAEELWLRLGHTTSLANGPFPQADPAYLVDDTVEYPVQVNGKIRGRIVVAADADYDTLKTVALADDKVQQFLAGATPRKVIVVAGRLISLVI
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