Gene ML0041
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Possible secreted protease |
| Comments | ML0041, len: 446 aa. Possible secreted protease (EC 3.4.21.-), highly similar to Rv3883c|O05461|AL123456 Possible secreted protease from M. tuberculosis (446 aa), Fasta scores: E(): 0, (79.1% identity in 446 aa overlap). Shows weaker similarity to known bacterial proteases e.g. Q46541|L18984 acidic protease V5 from Bacteroides nodosus aprV5 (595 aa), Fasta scores: E(): 1.8e-07, (28.1% identity in 442 aa overlap). Also similar to ML1538 and ML2528 from M. leprae. Previously sequenced as O33076|Y14967 (446 aa), Fasta scores: E(): 0, (99.8% identity in 446 aa overlap). Contains a probable N-terminal signal sequence. Contains 2 Pfam matches to entry PF00082 Peptidase_S8, Subtilase family. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 50656 | 51996 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0041|mycP1
VHRILLMMVALALLYAPPALAINPPSIDPGAVPPDVTGPDQPTEQKVMCSAPTTLPDSSFHDPPWSNIYIGVSEAHKFATGAGVTVAVIDTGVEASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIGGRPAPTDGFIGVAPDVRLLSLRQTSEAFQPVGVQPNANDPNAIPAAGSIRSLARAVVHAANLGASVINISETACYKANKPLDESTLGAAINYAVNVKGVVIIVAAGNTGGDCTQNPMPDVSMPNDPRGWSKVQTIATPAWYAPLVLTVGGIAQNGMPSQFSVHGPWVSVAAPTENITTLGYNGEPVNALPGEEGPVALAGTSFATAYVSGLAALLRQRFPDLTPAQIINRIIATARHPGGGVDDIVGAGVIDAVAALTWDITPGSASELFNVRSVPPPVITPGPDRNTIMIVAQGILGLSIALGLGVLVRRALQRQ
Bibliography
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