Gene ML0052c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameeccCb1
Gene length1794 bp
IdentifierML0052c
Location 63319 bp
Protein summary information
Molecular mass65179.2 Da
Isoelectric point6.73
Protein length598 amino acids
Structural information
PFAMPF01580
Orthologs
M. tuberculosis H37RvRv3871
M. lepromatosis Mx1-22AMLPM_0052
Cross-references
UniProtQ9CDD7
Gene OntologyDna binding, Cell cycle, Cell division, Chromosome segregation, Integral to membrane, Nucleoside-triphosphatase activity, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductESX CONSERVED COMPONENT ECCCB1
CommentsML0052c, len: 597 aa. esx conserved component, highly similar to Rv3871|O69736|AL123456 conserved hypothetical protein from M. tuberculosis (591 aa), Fasta scores: E(): 0, (80.9% identity in 596 aa overlap). Show some similarity with the C-terminal part of several proteins while the upstream ML0053 is similar to the corresponding N-terminal part e.g. O86653|AL031231 putative ATP/GTP-binding proteins from Streptomyces coelicolor (1321 aa), Fasta scores: E(): 0, (34.7% identity in 574 aa overlap); Rv3447c|O06264|AL123456 unknown membrane protein from M. tuberculosis (1236 aa), Fasta scores: E(): 0, (35.2% identity in 588 aa overlap); and Rv1784. Related proteins are also found in Bacillus spp. Similar to the C-terminal halves of ML1543 and ML2535. Previously sequenced as O33086|Y14967 (597 aa), Fasta scores: E(): 0, (99.7% identity in 597 aa overlap). Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS6331965112-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0052c|eccCb1
MTAEPEVRALREVVLEQLGTGESLAYKMWLPPLLDPLPLNELIERDSNRHPLHFALGIMDEPRRHRQDIWGVDLSGAGGNIGIGGAPQTGKTTLLQTMVMSAAATHSPRDVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDRINRVIAEAQAVMRQREITFKENRVGSMAAYRQLRTNRSHPVAADPFGDVFLIIDGWSAFTSEFPDLEAAVQDLAAQGLSFGVHTVITTPRWTELRSRVRDYLGTKIEFRLGDVNDTQIDRIARDIPANRPGRAISVEKHHLMMGVPRFDGAHSADDLVDAMTAGVAQIAAKTTEQAPRVRVLPSQVYLQEIDPNPPGPDSDYRTRWTIPVGVRETDLSVAYAHMSSNPHLLIFGNSKSGKTRIVHAIARAICARNSPKQVRFMLADYRSSLLDAVPDSHLLDAGAINRNSASLDEAIRALTTNLKKRLPPADLTTAQVRSRSWWSGFDVVLLVDDWHMIVSAAGSAPPMGPLAPLLPAAPDIGLHILVTCLMSQAYKATMDKFVGSAFGAGAPTIFLSGDKQEFPSSEIKVKRRPPGQAFMVSPEAKEVIQAVYVDPPEVDPPKEVFAVPPASS
Bibliography