Gene ML0053c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | ESX CONSERVED COMPONENT ECCCA1. POSSIBLE TRANSMEMBRANE PROTEIN. |
| Comments | ML0053c, len: 744 aa. esx conserved component, possible transmembrane protein, highly similar to Rv3870|O69735|AL123456 conserved transmembrane protein from M. tuberculosis (747 aa), Fasta scores: E(): 0, (85.4% identity in 746 aa overlap). Show some similarity with the N-terminal part of several proteins while the downstream ML0052 is similar to the corresponding C-terminal part e.g. O86653|AL031231 putative ATP/GTP-binding proteins from Streptomyces coelicolor (1321 aa), Fasta scores: E(): 0, (34.7% identity in 760 aa overlap); Rv3447c|O06264|AL123456 unknown membrane protein from M. tuberculosis (1236 aa), Fasta scores: E(): 0, (37.2% identity in 732 aa overlap); and Rv1784. Related proteins are also found in Bacillus spp. Similar to the N-terminal halves of ML1543 and ML2535. Contains hydrophobic, possible membrane-spanning region near the N-terminus. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 65186 | 67420 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0053c|eccCa1
MTTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCIVGMIAIMVLGGTKQLSPYMLMMPIMMVMMMAGGSGGGGGGKKVPEINADRKEYLRYLAGLRARVTSSAASQVAFFSYHAPHPQDLLSIVGTQRQWSRPANADFYAATRIGVGDQPAVDRLLKPAVGGELTASGAAPQPFLEPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMICHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMIFTRSDSLADLMSRGPHAPDSLPGGPYVILVDLTGGKAGFPPDGRAGVTVITLGNHRSSTYRIRVNKNGTADDRLPGQSFRQVTSTVDHLSKAEATRIARKLAGWSITGTILDKTSRVQKKVATEWHQLVGANTVEEVLPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIGTTGSGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQNILRQAGTLVGAAGALSGVAEYEKYRERGANLAPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRIGMEDPVKFSSLYTGIPFVPAIATETNGDSSPSSPWASRKKVHIYEFTAAPILESTTTS
Bibliography
- [2009]. Systematic genetic nomenclature for type VII secretion systems. Nomenclature Product
