Gene ML0055c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameeccA1
Gene length1722 bp
IdentifierML0055c
Location 68866 bp
Protein summary information
Molecular mass62342.3 Da
Isoelectric point4.81
Protein length574 amino acids
Structural information
PFAMPF00004
Orthologs
M. tuberculosis H37RvRv3868
M. lepromatosis Mx1-22AMLPM_0055
Cross-references
UniProtO33089
Gene OntologyNucleoside-triphosphatase activity, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductESX CONSERVED COMPONENT ECCA1
CommentsML0055c, len: 573 aa. esx conserved component, member of the CBXX/CFQX family of hypothetical proteins; C-terminal end is highly similar to many e.g. SP5K_BACSU|P27643 SpoVK/SpoVJ, stage V sporulation protein from Bacillus subtilis (322 aa), Fasta scores: E(): 3.5e-26, (33.7% identity in 332 aa overlap). Also highly similar to several M. tuberculosis hypothetical proteins e.g. Rv3868|Y2G8_MYCTU|O69733 hypothetical protein of the CBXX/CFQX family from M. tuberculosis (573 aa), Fasta scores: E(): 0, (89.2% identity in 573 aa overlap); and Rv0282. Previously sequenced as Y2G8_MYCLE|O33089 (573 aa), Fasta scores: E(): 0, (100.0% identity in 573 aa overlap). Similar to ML1536 and ML2537 from M. leprae. Shows weak similarity to ML0798. Contains Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA). Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS6886670587-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0055c|eccA1
MIDRLGSLFESAASMLPMSEARSFELFTEITNYDETACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQIPMTTLNARVPIGGLYGDITYPVTSPLAITMGFAACEAAQGNFADAMEAIDATSITGSEHLVAWLKAVVYGAAERWTDVIDEVKGAGKWPDKFLAGAAGVAHGVAAANLGLFTEAERRLTEANDSPAGEACARSIAWYLAMARRSQGNEDAAVALLEWLQTTHPESKVSAALKDPSYRLTTTTAEQIAARADPWDPSSVVTDNSDRDRLLTQAQAELDRQIGLTRVKTQIERYRAATMMAKVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVISEPKLVETSRKDFVAEYEGQSAVKAAKTIDLALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPDELLEIAKVIATDADSSLSAEASKNLLEAAKQLAQRTLRGRPALDVAGNGRYARQLVEAAEQCRDMRLARGVDIEQLDVDRLQEINGSDMAEAIATVHAHLNIRE
Bibliography