Gene ML0078 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepheA
Gene length969 bp
IdentifierML0078
Location 98425 bp
Protein summary information
Molecular mass33517.1 Da
Isoelectric point5.0
Protein length323 amino acids
Structural information
PFAMPF00800, PF01842
Orthologs
M. tuberculosis H37RvRv3838c
M. lepromatosis Mx1-22AMLPM_0078
Cross-references
UniProtQ9CDC4
Gene OntologyAmino acid binding, Prephenate dehydratase activity, L-phenylalanine biosynthetic process
Enzyme Classification4.2.1.51
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible prephenate dehydratase PheA
CommentsML0078, len: 322 aa. Possible pheA, prephenate dehydratase (EC 4.2.1.51) (see citation below), highly similar to Rv3838c|P96240|AL123456 pheA, prephenate dehydratase from M. tuberculosis (321 aa), Fasta scores: E(): 0, (83.9% identity in 311 aa overlap). Similar to PHEA_AMYME|Q44104 pheA, prephenate dehydratase from Amycolatopsis methanolica (304 aa), Fasta scores: E(): 0, (44.4% identity in 315 aa overlap). Contains Pfam match to entry PF01842 ACT, ACT domain. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase. Contains PS00858 Prephenate dehydratase signature 2.
Functional categoryIntermediary metabolism and respiration
Coordinates
TypeStartEndOrientation
CDS9842599393+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0078|pheA
VSVARIAYLGPEGTFTEAALLRMTAAGLVPDTGPDGLRRWPTESTPAALDAVRGGAADYACVPIENSIDGSVAPTLDNLAIGSPLQVFAETTLDVEFNIVVKPGITAADIRTLAAFPVAAAQVRQWLAAHLAGAELRPAYSNADAARQVAYGQVDAAVTSPLAATRWGLIALAAGIVDEPNARTRFVLVGMPGPPPARTGTDRTSAVLRIDNAPGMLVAALAEFGIRGIDLTRIESRPTRTELGTYLFFVDCVGHIDDGVVAEALKALHRRCADVCYLGSWPAGLATGPTVSPPPPDEASRWLARLRAGKPDQASEPGGGKL
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