Gene ML0132
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) |
| Comments | ML0132, len: 680 aa. Probable fadD29, fatty-acid-CoA synthetase (EC 6.2.1.-), similar to various mycobacterial enzymes believed to be involved in polyketide or fatty acid synthesis. Highly similar to Rv2950|P95141|AL123456 fadD29, fatty-acid-CoA synthetase from M. tuberculosis (619 aa), Fasta scores: E(): 0, (80.2% identity in 620 aa overlap); and similar to P71495|U75685 acyl-CoA synthase from Mycobacterium bovis BCG (582 aa), Fasta scores: E(): 0, (58.5% identity in 585 aa overlap); and to domains of polyketide synthases e.g. Q50857|U24657 safB, saframycin Mx1 synthetase B from Myxococcus xanthus (1770 aa), Fasta scores: E(): 0, (36.2% identity in 589 aa overlap). Also similar to ML0100, ML0138, ML1234 and ML2358 from M. leprae. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. |
| Functional category | Lipid metabolism |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 177170 | 179212 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0132|fadD29
MLRRVISLVVSAKSHVLYPAIVGPHQISRRGAGPSMKRRLGFEDTVAKRSYLLAVKSRRIIMKANVSFHARGEVATQPAQGPPEQTGQLVNGTATRFAMGESMLTDLLQKAASQFPNRAAYKFIDYDVDPAGFTETLTWWQVYRRSMSVAYELRIYASDGDRVAILAPQGLEYIVAFMGALQAGLIAVPLPAPQFGIHDERISAALRDSLPSVIITTSAAIVEVTKYAPHARSAQGSAPVVVAVDVLDLDSPRELDPSRYERLNTAYLQYTSGSTRAPAGVIVSHKNVITNCVQLMSDYLGDIEKVPSTAVSWLPFYHDMGLILGVILPMVNQDTAVLLSPMAFLQRPARWMQLLGKYRGQISCAPNFGFELAVRRTSDDDMAGLDLGHVRAIATGAERVNAATLQRFTERFARFNLDETAIRPSYGLAEATVYVATAGPGRPPKSICFDYQHLSAGKAKRSANGAGDGVNLVSYGAPRASVLRIVDPDTRIETSEGTVGEIWVQGDNVARGYWRNPENTERTFGGQLVNPSPGTPDGPWLRTEDLGVIFEGELFITGRIKDLLVVDGSNHYPDDIEATIQEITGGRVVAIAVPDDCTEQLVTIIELTKWGYADCDAMEKLCTVKREVTSAVSKSHRVRVADVVIVAPGSIPVTTSGKVRRAACVERYLNHEFNRLDATA
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