Gene ML0135
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable polyketide synthase Pks1 |
| Comments | ML0135, len: 2103 aa. Probable pks1, polyketide synthase, The N-terminus is highly similar to Rv2947c|P96284|Z83858 pks15, probable polyketide synthase (496 aa), Fasta scores: E(): 0, (90.5% identity in 485 aa overlap); and the remainder is highly similar to Rv2946c|P96285|Z83858 pks1, probable polyketide synthase (1616 aa), Fasta scores: E(): 0, (82.5% identity in 1620 aa overlap). Also similar to many polyketide synthases from M. tuberculosis and other bacteria e.g. AAF71776|AF263912 NysC, nystatin biosynthesis polyketide synthase from Streptomyces noursei (11096 aa), Fasta scores: E(): 0, (50.2% identity in 2161 aa overlap). And similar to ML0101, ML0139, ML1229, ML2353, ML2354, ML2355, ML2356 and ML2357 from M. leprae. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site. |
| Functional category | Lipid metabolism |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 182173 | 188484 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0135|pks1
MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTGIFAPSYGSRDTGGLQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVEGRPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTADQQRLSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALAARSVFEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADAGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEGVGIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAVVVSMMGKDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAVSVYSRGDQSHGGWLLNAEGLLEVDAAEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPTGVVVDGMGMHPALLDAVLHALGLAIENTQATTEMRLPFCWRGVSLHAGGAGRVRARFTSAGADAIAVDIADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGGALEQGPMDLVWSPIPLSSDGHGGGLPSVVSWADYCAGRGNDTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFGQDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSGKIVLIDTDSAVDVAVLADLGESQLLVRCNTVHAARLSPAPQLLALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATGLTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA
Bibliography
No article yet recorded
