Gene ML0174
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Mycobacterial persistence regulator MrpA (two-component response transcriptional regulatory protein) |
| Comments | ML0174, len: 228 aa. Probable mprA, mycobacterial persistence regulator, a two-component response regulator whose expression is required for entry and maintenance of persistent infections (see citation below), equivalent to Rv0981|O53894|AL123456 mprA, regulator part from a two-component response regulator system from M. tuberculosis (230 aa), Fasta scores: E(): 0, (94.3% identity in 228 aa overlap); and several other putative two-component response regulators e.g. COPR_PSESM|Q02540 copR, transcriptional activator protein involved in activation of copper resistance from Pseudomonas syringae (227 aa), Fasta scores: E(): 6.4e-32, (43.9% identity in 223 aa overlap). Also similar to ML0773, ML1286, ML2123 and ML2439 from M. leprae. Previously sequenced as Q9Z5G8|AL035500 (253 aa), Fasta scores: E(): 0, (100.0% identity in 228 aa overlap). Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. |
| Functional category | Regulatory proteins |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 240531 | 241217 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0174|mprA
VRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
Bibliography
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